The HaMM Lab

The HaMM Laboratory provides opportunities for students interested in pursuing research on metabolic adaptations that occur in both cardiac and skeletal muscle. 

Dr. Kolwicz has a long-standing interest in the role of lipid metabolism in the development of cardiac dysfunction.  His past work, using genetic approaches, revealed a potential of enhanced cardiac lipid metabolism to protect the heart from acute and chronic stressors.  Current and future work will investigate the metabolic adaptations that occur in both cardiac and skeletal muscle during acute and chronic exercise training.  

The Heart and Muscle Metabolism Laboratory is located in IDC 216.The Heart and Muscle Metabolism Laboratory is located in IDC 216.

Recent Student Projects

  • Ken Sprankle, “Exploring sex differences in mice fed the ketogenic diet”
  • Mya Knappenberger, “Behavioral changes in female mice fed a high fat diet”
  • Caitlin O’Neill, “The effects of exercise training on glucose homeostasis in Type I diabetic female mice”
  • Lola Holcomb, “Differences in endurance exercise and metabolic gene expression in male and female mice”
  • Katie Kurzinsky, “The effects of ketogenic diet on Type I diabetes in mice”
  • Brooke Segich, “Oxidative stress in the hearts of mice fed a high saturated or high unsaturated fat diet”
  • Elizabeth DeWitt, Ian Dysinger, Zachary Larmer: “High saturated and unsaturated fat diets yield different disease phenotypes in mice.”
  • Patrick Rowe, Caitlin O’Neill, Elizabeth DeWitt: “Endurance exercise capacity and substrate metabolism in male and female mice.”
  • Zachary Larmer, Elizabeth Dewitt: “The effects of ketogenic diet on metabolic parameters in obese mice.”

Innovation and Discovery Center

The HaMM Lab is located in the
Innovative Discovery Center, IDC#216.

 

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