All Majors & Minors

Nathan T. Scharf

Dr. Nathan Scharf grew up in rural western New York, receiving his undergraduate degree in chemistry and biology at The College at Brockport, State University of New York. Dr. Scharf then went to the University of Michigan to cheer on the Wolverines in football and earn his Ph.D. in Medicinal Chemistry under Prof. George Garcia. Dr. Scharf then joined the Department of Chemistry at Ursinus as a Visiting Assistant Professor.

Dr. Scharf’s primary research interests are infectious diseases and antibacterial drug discovery. Dr. Scharf aims to develop assays to characterize and assess the activity of essential enzymes that could be targeted for infectious diseases.

In his spare time, Dr. Scharf enjoys playing a variety of sports and activities; including soccer, volleyball, ice hockey, and rock climbing.


Assistant Professor, Visiting




B.S., The College at Brockport, State University of New York
Ph.D., University of Michigan


General Chemistry I Lab (CHEM-105L)
Biophysical Chemistry (BCMB-307)
Fundamentals of Biochemistry (CHEM-347)
Biochemistry II: Metabolism (BCMB-452W)

Research Interests

Infectious diseases
Drug discovery

Recent Work

Vadim Molodtsov, Nathan T. Scharf, Maxwell A. Stefan, George A. Garcia, Katsuhiko S. Murakami. Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis. Mol. Microbiol. 2017, 103(6), 1034-1045.

Nathan T. Scharf, Vadim Molodtsov, Arrin Kontos, Katsuhiko S Murakami, George A. Garcia. Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening. SLAS Discov. 2017, 22(3), 287-297.

Vadim Molodtsov, Irosha N. Nawarathne, Nathan T. Scharf, Paul D. Kirchhoff, H. D. Hollis Showalter, George A. Garcia, and Katsuhiko S. Murakami. X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins. J. Med. Chem. 2013, 56(11), 4758-4763.