Stephen C. Kolwicz, Jr became a member of the Health and Exercise Physiology Department at Ursinus College in 2017. After receiving a BS in Wellness Studies and MS in Clinical Exercise Physiology, he worked for several years in both in-patient and outpatient cardiac rehabilitation settings before deciding to pursue a PhD in Exercise Physiology. After completing postdoctoral training, Dr. Kolwicz was appointed as a research faculty in the Mitochondria & Metabolism Center at University of Washington. In addition to past clinical and research experiences, Dr. Kolwicz held adjunct instructor positions at both Rowan University and Temple University. When not in the classroom, Dr. Kolwicz provides undergraduate research experiences in understanding the metabolic adaptations to exercise.
- B.S., Rutgers University-Camden
- M.S., East Stroudsburg University
- Ph.D., Temple University
- NMR Laboratory for Physiological Chemistry, Brigham and Women’s Hospital, Harvard Medical School
- Mitochondria & Metabolism Center, University of Washington
Dr. Kolwicz has a long-standing interest in the role of lipid metabolism in the development of cardiac dysfunction. His past work, using genetic approaches, revealed a potential of enhanced cardiac lipid metabolism to protect the heart from acute and chronic stressors. Current and future work will investigate the metabolic adaptations that occur in both cardiac and skeletal muscle during acute and chronic exercise training.
Nguyen S, Shao D, Tomasi LC, Braun A, de Mattos ABM, Choi YS, Villet O, Roe N, Halterman CR, Tian R, Kolwicz SC Jr. The effects of fatty acid composition on cardiac hypertrophy and function in mouse models of diet-induced obesity. Journal of Nutritional Biochemistry, 46:137-142, 2017. PMID: 28605665
Choi YS, de Mattos AB, Shao D, Li T, Nabben M, Kim M, Wang W, Tian R, Kolwicz SC Jr. Preservation of myocardial fatty acid oxidation prevents diastolic dysfunction in mice subjected to angiotensin II infusion. Journal of Molecular Cellular Cardiology, 100:64-71, 2016. PMID: 27693463
Kolwicz SC Jr. Lipid partitioning during cardiac stress. Biochimica et Biophysica Acta, 1861(10):1472-80, 2016. PMID: 27040509
Kolwicz SC Jr, Liu L, Goldberg IJ, Tian R. Enhancing cardiac triacylglycerol metabolism improves recovery from ischemic stress. Diabetes, 64(8): 2817-27, 2015. PMID: 25858561
Kolwicz SC Jr, Purohit S, Tian R. Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circulation Research, 113(5):603-16, 2013. PMID: 23948585
Kolwicz SC Jr, Olson DP, Marney LC, Garcia-Menendez L, Synovec RE, Tian R.Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy. Circulation Research, 111(6):728-38, 2012. PMID: 22730442