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  • Evan Scott

Evan Scott

Examining Permeability and Contractility of Skeletal Muscle in Castrated Male Mice

Project Description

A common method of treating skeletal muscle injury is temperature therapy. Temperature affects one of the initial aspects of skeletal muscle healing, the increasing of vascular permeability. Previous data accumulated from the Ursinus College Skeletal Muscle Lab suggests that vascular permeability following temperature therapy is different between the anatomically intact male and female mice. However, there have not been any studies to date that are able determine the cause of these permeability differences following temperature treatment. In addition, it is currently unclear how increased vascular permeability affects skeletal muscle healing. A possible cause for these differences is the increased presence of testosterone in males compared to females. To investigate this, temperature therapy was conducted on 4 castrated male mice with four other castrated male mice as the control group. Moreover, the contractility differences in healed muscle in these mice was to be examined. However, due to unforeseen circumstances, the results for this experiment are limited. This paper will focus more on the methods and future plans of my experiment should it be conducted in full.

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Health and Exercise Physiology

Faculty Advisor

April Carpenter


Ambler, PA