Marcus J. Wagner, PhD is a Visiting Assistant Professor and Cardiac Physiologist. He graduated from Ursinus College with a B.S. degree in Biology (with honors) in 2017. Marcus pursued his PhD in Biomedical Sciences with a concentration in Organ Systems and Translational Medicine from Temple University’s Lewis Katz School of Medicine. While at Temple, he also earned a Certificate in Higher Education. Dr. Wagner pursued a post-doctoral fellowship in Dr. Sharlene Day’s laboratory at the University of Pennsylvania and was awarded a prestigious post-doctoral fellowship from the Brody Family medical trust. He has instructed courses at Ursinus since 2020 and has come on has joined the Biology Department full-time in 2023. Dr. Wagner loves working with his student researchers and strives to help all his students be successful. In his spare time, Dr. Wagner volunteers on the alumni council at Ursinus College and as an assistant swim coach for the Men and Women’s swim team.
Hypertrophic Cardiomyopathy (HCM) is a familial, genetically based disease that affects 1 in 500 people. HCM patients exhibit a progressive, symptomatic disease burden that results in adverse cardiac outcomes including heart failure and early mortality. Current therapies are largely palliative for symptomatic benefit only. The Wagner lab aims to better understand the underlying pathophysiology of HCM bycharacterizing cardiac function and the cardiac immune cell landscape of the HCM heart. The lab is actively pursuing projects that assess the effects of sarcomeric and non-sarcomeric gene variants their effects on cardiac function. Additional projects are designed to study the effects exercise has on the cardiac immune cell landscape in the presence of physiological stressors (exercise, high fat diet, and HCM).
- B.S. (with honors), Ursinus College
- Ph.D., Lewis Katz School of Medicine, Temple University
- BIO306: Human Physiology
- BIO306L: Human Physiology Lab
- BIO102: Cell Biology
- BIO102L: Cell Biology Lab
- Investigating the pathophysiology of Hypertrophic Cardiomyopathy; particularly how genetic variants in sarcomeric and non-sarcomeric genes regulate disease pathology.
- Identifying novel therapeutics and interventions that treat the symptoms and pathophysiology of Hypertrophic Cardiomyopathy.
- Delineating immune cell population dynamics resident in the cardiac tissue and how different physiological stressors (diet, disease, and exercise) modify such populations.
- Thompson A, Wagner M, Rodriguez J, et al. An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3. J Am Coll Cardiol Basic Trans Science. null2023, 0 (0) .https://doi.org/10.1016/j.jacbts.2023.04.009
- Kraus L, Bryan C, Wagner M, Kino T, Gunchenko M, Jalal W, Khan M, Mohsin S. Bmi1 Augments Proliferation and Survival of Cortical Bone-Derived Stem Cells after Injury through Novel Epigenetic Signaling via Histone 3 Regulation. Int J Mol Sci. 2021 Jul 22;22(15):7813. doi: 10.3390/ijms22157813. PMID: 34360579; PMCID: PMC8345961.
- Wagner, M.J., Menzer, J.T., and Mohsin,S. Inflammation, Stem Cell Therapy, and Cardiac Repair. CRC Press/Taylor and Francios. (2021).
- Kurian J, Yuko AE, Kasatkin N, Rigaud VOC, Busch K, Harlamova D, Wagner M, Recchia FA, Wang H, Mohsin S, Houser SR, Khan M. Uncoupling protein 2-mediated metabolic adaptations define cardiac cell function in the heart during transition from young to old age. STEM CELLS Translational Medicine.;n/a. doi:10.1002/sctm.20-0123.
- Wagner, M. J., Khan, M. & Mohsin, S. Healing the Broken Heart; The Immunomodulatory Effects of Stem Cell Therapy. Front. Immunol. 11, (2020).